Protection of hearts from reperfusion injury by propofol without involvement of the mitochondrial ATP-sensitive potassium channels
- VernacularTitle:线粒体ATP敏感性钾通道不参与异丙酚预处理的心肌保护
- Author:
Cuimei WANG
;
Hong CAO
;
Tijun DAI
;
Yinming ZENG
;
- Publication Type:Journal Article
- Keywords:
mitochondrial ATP sensitive potassium channels;
propofol preconditioning;
K ATP;
MDA;
LVEDP
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
0 05) group. Treatment with propofol or the combination of propofol and 5 HD delayed the onset of contracture during ischemia compared with control or 5 HD treatments for (6 4?2 1) min or (6 8?2 5) min vs (4 4?1 4) min or (4 2?1 6) min, respectively; P 0 05). The LVEDP in propofol or propofol plus 5 HD increased more slowly than in the control or 5 HD group. Maximal LVEDP occurred 17 min or 16 min,respectively after ischemia in the control group,whereas it occurred 20 and 22 min after ischemia in propofol and propofol plus 5 HD groups, respectively( P
