Comparison of berberine between normal and febrile rats——pharmacokinetic study of antifebrile complex YL2000
- VernacularTitle:解热药YL2000中小檗碱在正常和发热大鼠体内的药物动力学比较
- Author:
Yunan ZHAO
;
Dongming XING
;
Yi DING
;
Wen JIN
;
Wei WANG
;
Fan LEI
;
Lijun DU
;
- Publication Type:Journal Article
- Keywords:
YL2000;
berberine;
fever;
pharmacokinetics, rat
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore pharmacokinetics of Berberine in YL2000 in normal and febrile rats. METHODS The levels of Berberine in plasma were measured through HPLC and secondary parameters were obtained by fitting the dose time data of Berberine making use of 3P87 programme. RESULTS In normal and febrile rats, the plasma concentration of Berberine was peaked at (3 4?0 3) h vs (0 3?2 1) h( P
