Effect of ginkgo biloba exocarp polysaccharides (GBEP) on p53 gene expression and telomerase activity of human gastriccancer SGC-7901 cells
- VernacularTitle:银杏外种皮多糖对SGC-7901细胞p53基因的表达及端粒酶活性的影响
- Author:
Aihua XU
;
Huasheng CHEN
;
Gang CHEN
;
Qing SU
;
Buchan SUN
;
Yulan GU
;
- Publication Type:Journal Article
- Keywords:
ginkgo;
polysaccharides;
gastriccancer cell;
p53 gene;
telomerase
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the influence of ginkgo biloba exocarp polysaccharides(GBEP) on p53 gene expression and telomerase activity of human gastriccancer SGC 7901 cells in vitro . METHODS The p53 gene expression level of human gastriccancer SGC 7901 cells were measured by immunohistochemistry ABC. The telomerase activity of human gastriccancer SGC 7901 cells were measured by TRAP ELISA. RESULTS GBEP(80～160 mg?L -1 ,48 h) inhibited the expression of mutated type p53 genes and telomerase activity of human gastriccancer SGC 7901 cells. CONCLUSION The action mechanism of GBEP that inhibited the proliferation of SGC 7901 cells may relate to its down regulation effect on the expression of p53 genes and telomerase activity of human gastriccancer SGC 7901 cells.
