Effects of misgurnus anguillicaudatus polysaccharides on antihypoxia capacity in mice
- VernacularTitle:泥鳅多糖对小鼠耐缺氧作用的研究
- Author:
Jun ZHOU
;
Chenxiao ZHANG
;
Kaixun HUANG
;
- Publication Type:Journal Article
- Keywords:
misgurnus anguillicaudatus;
polysaccharide;
antihypoxia
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM The effects of misgurnus anguillicaudatus Polysaccharides(MAP) on the antihypoxia capacity in mice were studied. METHODS The mice were administered with various doses of MAP for 14 days and then were exposed to hypoxia. The survival time in mice, the content of hemoglobin (Hb), the content of MDA and the activity of superoxide dismutase (SOD) were examined. RESULTS MAP significantly prolonged the survival time in mice exposed to hypoxia. The optimal dose was 50 mg?kg -1 ?d -1 . MAP could inhibit lipid peroxidation in tissues, and increase Hb content and the activity of SOD in plasma. CONCLUSION MAP are the biological active components in Misgurnus anguillicaudatus against hypoxia.
