The effect of recipient kidney function by Ber coadministration CsA used to induce immune tolerance in rats of allogenic cardiac transplantation
- VernacularTitle:小檗碱联用环孢素诱导免疫耐受后对肾功能的影响
- Author:
Xinghua NI
;
Yaoying ZENG
;
Jingfang DI
;
Xianhui HE
;
Tongcheng LIU
;
Yi LIN
;
Wenyue XIE
;
Shan ZENG
;
Zheng FENG
;
- Publication Type:Journal Article
- Keywords:
berberine;
cyclosporine;
immune tolerance;
heterotopic cardiac transplantation;
kidney function
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effect of recipient kidney function by CsA coadministration Ber used to induce immune tolerance in rats of allogenic cardiac transplantation. METHODS The authors established the SD to Wistar rats heterotopic cardiac transplantation model by Onos methods.Observe the cardiac allograft survival and levels of BUN and Cr in the recipients plasma. The recipients were classified into 5 groups randomly after heterotopic cardiac transplantation were performed. Group A (Wistar to Wistar)): Received placebo intraperitoneal injected for 21 days; Group B (SD to Wistar): Saline intraperitoneal injected for 21 days; Group C (SD to Wistar):CsA 2 mg?kg -1 ?d -1 intraperitoneal injected for 21 days; Group D(SD to Wistar):Ber 16 mg?kg -1 ?d -1 gastrointubation for 21 days; Group E(SD to Wistar): Ber 16 mg?kg -1 ?d -1 gastrointubation coadministration CsA 2 mg?kg -1 ?d -1 ip for 21 days. RESULTS The levels of BUN and Cr in recipint plasma is lower evidently compare with the group with CsA ip simply. CONCLUSION Ber can reduce the renal toxicity in recipients by CsA which was intraperitoneal injected (ip) over a long period time.
