Experimental research on the effect of neostigmine on the clearance rate of small molecular substances in the blood secreted by small intestine
- VernacularTitle:新斯的明对小肠分泌血液中小分子物质清除率影响的实验研究
- Author:
Debin HUANG
;
Zeyun LIAO
;
Zehua HU
;
Deqing LI
;
Zhaofen YU
;
Yushan LI
;
- Publication Type:Journal Article
- Keywords:
neostigmine;
small intestine loop;
clearance rate;
experimental study
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM Research on effective dialysis medicine through partial isolation loop of small intestine to treat renal failure. METHODS Divide 10 dogs equally into group A and group B for comparative study: make full isolation loop of small intestine; input hypersonic sample solution through vein after blocking the renal arteries to make the man made real failure models such as electrolytic disorder, azotemia and so on. Then at 0 5 hour and 5 hours after that, inject 0 9% NaCl 0 5 ml for group A and 0 025 mg?kg -1 of neostigmine for group B. Finally collect the secretion fluid of the small intestine loop and blood samples every 30 minutes from group A and group B respectively so as to determine the density of K + ,Na +, Cl -,UN, CR,UA in the small intestine fluid and blood samples of the two groups and calculate the clearance rate of each group. RESULTS Respectively at 1 5 hours and 6 5 hours after being injected with neostigmine, group B got two secretion peaks and its clearance rate is remarkably higher than that of group A( P
