Relationship between glutamate transporter, glutamate/cysteine transporter and neurotoxicity induced by glutamate
- VernacularTitle:谷氨酸转运体、谷氨酸/胱氨酸转运体与谷氨酸神经细胞毒作用
- Author:
Xichong YU
;
Tongjun ZHU
;
- Publication Type:Journal Article
- Keywords:
pharmacology;
reviews;
glutamate transporter;
glutamate/cysteine transporter;
neurotoxicity
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
This paper introduces the relationship between glutamate transporter, glutamate/cysteine transporter and neurotoxicity induced by glutamate. Under pathologic conditions, glutamate transporters release glutamate to activate glutamate receptors, and inhibit the uptake of glutamate/cysteine transporters, which induces downstream changes. Among these changes oxygen derived free radidicals affects the function of glutamate transporter and enhances the neurotoxicity of glutamate. All these can lead to neurocyte death. Glutamate transporters release glutamate to inhibit the uptake of glutamate/cysteine transpoter and activate glutamate receptor. The inhibition of glutamate/cysteine transpoter affects the function of glutamate transporter. Two transporters interaction and the downstream changes lead to neurocytes death.
