Evaluation of efficacy and safety of rifamycin sodium injection in treatment of patients with pulmonary tuberculosis
- VernacularTitle:含利福霉素钠注射液方案治疗肺结核的有效性和安全性评价
- Author:
Yifeng JIN
;
Xiazhi ZHANG
;
Jiazhen XIE
;
Xiongwen TU
;
- Publication Type:Journal Article
- Keywords:
pharmacodynamics;
rifamycin sodium injection;
rifampin;
pulmonary tuberculosis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the therapeutic effect and safety of the rifamycin sodium injection (SV) in treatment of patients with pulmonary tuberculosis. METHODS: 44 cases of pulmonary tuberculosis were randomly allocated to two groups: rifamycin sodium group and routine treatment group. Chemotherapy regimens: in the rifamycin sodium group, 21 cases were treated with the regimen of 2HZE+SV/7HR; and in the routine treatment group, 23 cases were treated with the regimen of 2HRZE/7HR. RESULTS: The sputum negative conversion rate of the rifamycin sodium group was 85.7 %, and the foci vanishing rate was 90.5 %, while the both rates in the routine treatment group were 60.9 % and 60.9 %, respectively. There was significant difference between the two groups (P
