Roles of NF-?B activation and TNF-? expression in heart failure following myocardial infarction in rats
- VernacularTitle:NF-?B活化和TNF-?表达在大鼠心肌梗死后心力衰竭中的作用
- Author:
Ping XIE
;
Shanjun ZHU
;
Zhiming ZHU
;
- Publication Type:Journal Article
- Keywords:
nuclear factor kappa B;
tumor necrosis factor ?;
heart failure
- From:Journal of Third Military Medical University
2003;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of nuclear factor ?B (NF ?B) activation and tumor necrosis factor ?(TNF ?) expression on the progressive heart failure following myocardial infarction in rats. Methods Male rats were randomized for the proximal left anterior descending branch coronary artery ligation and then killed at 4, 8 and 12 weeks after ligation for the examination of hemodynamic parameters, ventricular mass index, protein expression of TNF ?, and NF ?B activity. Sham operated rats were used as the control group. Results Compared with the sham operated group, the myocardial infarction rats showed significant decreases in mean arterial pressure(MAP), maximal ascending and descending velocity of the left ventricular pressure(?dp/dt max ) and a significant increase in left ventricular end diastolic pressure(LVEDP) ( P
