Experimental study of the protective effect of endotoxin pretreatment on hippocampal neurons in rat forebrain following ischemia-reperfusion
- VernacularTitle:内毒素预处理对大鼠前脑缺血再灌注后海马神经元保护效应的研究
- Author:
Qiang XIANG
;
Jun YANG
;
Liang WEN
;
Minghua LIU
;
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
reperfusion;
pretreatment;
endotoxin
- From:Journal of Third Military Medical University
2003;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of endotoxin pretreatment on hippocampal neurons in rat forebrain following ischemia reperfusion and its possible mechanism. Methods Rat forebrain ischemia reperfusion model was used. The effects of endotoxin pretreatment on the changes of superoxide dismutase (SOD), glutathione peroxidase (GSH PX) and malondialdehyde (MDA) activities and the neuron count in CA1 region were observed. Results Pretreament with endotoxin before cerebral ischemia enhanced the activities of SOD and GSH PX but decreased MDA level and the number of ischemic neurons in CA1 region. Conclusion Endotoxin pretreatment can protect the neurons in rat forebrain against ischemia reperfusion injury. The mechanism may be associated with the enhancement of endogenous antioxidant activity in central nervous system.
