Transplantation of mesencephalon progenitor cells in treatment of Parkinsonian rats
- VernacularTitle:中脑祖细胞移植治疗大鼠帕金森病
- Author:
Zengmin TIAN
;
Feng YIN
;
Yaqi WANG
;
Shuang LIU
;
Ying ZHOU
;
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
mesencephalon;
progenitor cells;
transplantation
- From:
Academic Journal of Second Military Medical University
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the feasibility of mesencephalon progenitor cells as dopamine neuron's graft in treatment of Parkinson disease(PD) in rats. Methods: Animal model of PD were established in SD rats by 6 hydroxydopamine. Mesencephalon progenitor cells were obtained from 13 day old fetal rats. After in vitro proliferation and differentiation, the cells were planted into PD rat striatum. Results: Progenitor cells were expanded in an undifferentiated state with endothelia growth factor and basic fibroblast growth factor as mitogens. IL 1 and striatal culture media further increased the number of TH immunoreactive cells. Transplantation of these neurons relieved the rotation symptom of PD rats. Conclusion: Transplantation of mesencephalon progenitor cells has certain effects on PD rats.
