Birth, sex differentiation and immortalization of mammalian germ cells
- VernacularTitle:哺乳动物生殖细胞的形成、性分化和永生化
- Author:
Shanrong LIU
;
Kaimeng HU
;
Houqi LIU
;
Zhongtian QI
;
- Publication Type:Journal Article
- Keywords:
primordial germ cells;
sex differentiation;
immortalization;
review literature
- From:
Academic Journal of Second Military Medical University
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
The germ cell lineage in the mouse is established during gastrulation;sex determination is achieved after germ cell migrating to the site of the future gonads. Germ cells proliferate indefinitely when cultured in vitro . Human embryonic germ(EG) cells have been recently established;these immortalized EG cells are chromosomally stable and pluripotent, raising the hope that their differentiation can be directed to specific cell types, which may be of value in the clinical treatment of degenerative diseases.
