Enhancement effect of propofol on binding function of GABA_A receptor
- VernacularTitle:普鲁泊福对GABA_A受体结合功能的影响
- Author:
Yunfei CAO
;
Bei MA
;
Liqun YANG
;
Weifeng YU
;
- Publication Type:Journal Article
- Keywords:
propofol;
GABA A receptor;
binding function
- From:
Academic Journal of Second Military Medical University
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of propofol on the binding function of GABA A receptor. Methods: By using radioligand receptor binding assay, effects of propofol on the specific binding of 3H GABA and saturation curves of GABA A receptor were observed in cortical membrane preparations from mouse cerebral cortex. Results: Specific binding experiments showed that propofol at the concentrations of 10 300 ?mol/L markedly enhanced the specific binding of 3H GABA( P 0.05). Conclusion: Clinical concentrations of propofol can enhance the binding function of GABA A receptor through increasing the affinity of the low affinity binding site of GABA.
