Role of SOCS-3 on leptin resistant and obesity
- VernacularTitle:SOCS-3在瘦素抵抗及肥胖发病中的作用
- Author:
Shen QU
;
Dajin ZOU
;
- Publication Type:Journal Article
- Keywords:
suppressors of cytokine signaling;
leptin;
obesity;
review literature
- From:
Academic Journal of Second Military Medical University
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
The new protein suppressors of cytokine signaling(SOCS) as negative regulators of signaling pathways involve in the cellular actions of many cytokines, including leptin. It regulates intracellular signal transduction cascades such as the JAK STAT pathway. SOCS is now evident of leptin resistance and has close relation with obesity. We reviewed the structure and function of SOCS 3 and the mechanism in leptin signaling pathway,providing data for the potential effect of SOCS 3 in the treatment of obesity.
