Expression of survivin gene in human primary hepatic carcinoma and its relotionship with apoptosis
- VernacularTitle:Survivin在人原发性肝细胞癌中的表达及其与凋亡的相关性
- Author:
Chunsheng LI
;
Canrong NI
;
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
apoptosis;
proliferation;
Bcl xl;
Survivin
- From:
Academic Journal of Second Military Medical University
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
The expressions of survivin,PcNA and Bcl xl were detected in 68 patients with pramary hepatic careinoma(HCC) and adjacent tissues and 12 cases of normal hepatic tissues by immunohistochemical (IHC) EnVision and Tunel method.The relationship between survivin gene expression and apoptosis index(AI),proliferation index(PI) and apoptosis inhibition factors were studied.The positive rate of survivin and Bcl xl expression were 58.8%(40/86) and 48.5%(33/68) in HCC,5.88%(4/68) and 36.8%(25/68) in adjacent tissues,0 (0/12) and 25%(3/12) in normal hepatic tissues.The expression of Survivin and Bcl xl are mainly in cell membrane and cytoplasm.Survivin expression is related to metastasis of HCC ( P
