The electrophysiological properties of neurons in the developing visual cortex in rats
- VernacularTitle:大鼠发育过程中视皮层神经元电学特性的研究
- Author:
Yali TU
;
Yiingbing LIU
;
Li ZHANG
;
Yanjun ZHAO
;
- Publication Type:Journal Article
- Keywords:
whole cell recording;
patch clamp;
brain slice;
visual cortex;
polysynaptic response
- From:Journal of Third Military Medical University
2003;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the electrophysiological characteristics of neurons in developing visual cortex and to observe the reciprocal connection and the function of integration between adjacent neurons. Methods Whole cell recordings of the visual cortex from SD rats (4～28 d old) were obtained by using "blind" whole cell patch clamp recording technique. Bipolar stimulating electrodes were placed in the white border under the visual cortex. Postsynaptic currents(PSCs) were evoked by using stimulation of 0 1 Hz. Results There were three types of PSCs recorded in 156 cells in the first developmental month: irresponse, monosynaptic response and polysynaptic response. The incidence of polysynaptic PSCs increased from 12 36% before eye opening to 31 34% after eye opening ( P
