Double-blind study of the efficacy and safety of desloratadine for treating allergic rhinitis
- VernacularTitle:二类新药地洛他定治疗过敏性鼻炎临床疗效及安全性随机对照双盲试验
- Author:
Yinan WANG
;
Xianli YU
;
Changyou JI
;
Zhongzhan NI
;
- Publication Type:Journal Article
- Keywords:
allergic rhinitis;
treatment;
desloratadine
- From:Journal of Third Military Medical University
2003;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of desloratadine for the treatment of allergic rhinitis. Methods A total of 50 cases of chronic or acute allergic rhinitis confirmed clinically were randomized into control and experimental groups for double blind study. Scoring of clinical symptoms, examinations of the nasal cavity, blood and urine routine examination, functions of liver and kidney and electrocardiogram (ECG) were conducted on day 14 before and after the experiment. The collected data were analyzed statistically. Results The clinical data of the two groups were comparable. The effective rate of desloratadine was significant in allergic rhinitis, being 95.45%. No remarkable adverse effect was noted in this experiment. Conclusion Desloratadine is more effective and safe than loratadine in the treatment of allergic rhinitis and it may be feasible for clinical application.
