H_2S:the third endogenous gaseous transmitter
- VernacularTitle:第3种内源性气体信号分子
- Author:
Xiaoqing TANG
;
Jianqiang FENG
;
- Publication Type:Journal Article
- Keywords:
H 2S;
endogenous signaling gasotransmitter
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
It is hypothesized that H 2S is the third endogenous signaling gasotransmitter, after NO and CO. Endogenous H 2S may regulate some aspects of synaptic activity via cAMP mediated pathways and function as a neuromodulator or transmitter. H 2S is an endogenous vasorelaxant factor that activates K ATP channels and hyperpolarizes membrane potential of vascular SMCs. By directly acting on vascular SMCs, H 2S may reduce the extracellular calcium entry and relax vascular tissues.
