The effect of D-galactose on bone metabolism in mice and its mechanism
- VernacularTitle:D-半乳糖导致小鼠骨丢失及其机制初探
- Author:
Dongyun QIN
;
Tie WU
;
Liao CUI
;
Hongli WANG
;
Xiaoqin LIU
;
- Publication Type:Journal Article
- Keywords:
galactose;
bone metabolism;
bone hydroxyproline;
bone magnesium
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effects of D galactose on bone contents of hydroxyproline(HOP), calcium, microelements and activities of antioxidation in mice. METHODS Twenty female kunming mice at three months of age were used in this study. D galactose at dose of 1 g?kg -1 ?d -1 was given subcutaneous injection daily to the mice for 42 days. The right femurs were collected to determine the bone dry weight, bone hydroxyproline content, bone calcium, and bone microelements. The activities of catalase (CAT), glutathione peroxidase (GSH Px) and superozide dismutases (SOD) in blood, and contents of methylenedioxyamphetamine (MDA) in serum, lipofuscin in liver were determined. RESULTS The bone dry weight, hydroxyproline, calcium of bone decreased significantly in D galactose treaded group(compared with control group, P
