Anti-oxygen free radicals and anti-lipoperoxidation of sasanquasaponin(SQS) to myocardial ischemic rat
- VernacularTitle:油茶皂苷抗心肌缺血大鼠氧自由基和脂质过氧化作用
- Author:
Qiren HUANG
;
Ming HE
;
Ping LI
;
Weijie PENG
;
Shouyi CAO
;
- Publication Type:Journal Article
- Keywords:
malondialdehyde(MDA);
superoxide dismutase(SOD);
glutathione peroxidase(GSH Px);
Sasanquasaponin(SQS)
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM In this study, we observe the effects of SQS on contents of myocardial malondialdehyde(MDA)and activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH Px) through adopting the model of myocardial ischemic injury induced by subcutaneous injection of isoprenaline(ISO 4 mg?kg -1 ?d -1 ?2 d) into rats. METHODS Four groups were divided, namely NS, I/R, SQS1 and SQS2 group. The contents of MDA and activities of SOD and GSH Px were examined after administering SQS for 3 days(1 time per day). RESULTS The results show the elevation of S T in ECG, increase of MDA contents and decrease of SOD and GSH Px activities in I/R group. SQS may antagonize the changes of MDA, SOD and GSH Px induced by ISO, revealing the relationship to dose dependence. CONCLUSION SQS is most likely to possess the capabilities of anti oxygen free radicals and anti lipoperoxidation to myocardial ischemic injury induced by ISO.
