Inhibited effects of progesterone on contraction and cytomembrane Ca~(2+)-activated K~(+)currents in guinea pig colonic smooth muscles
- VernacularTitle:黄体酮对豚鼠结肠平滑肌及细胞膜钙依赖的钾通道电流的影响
- Author:
Long XU
;
Baoping YU
;
Mingkai CHEN
;
Weiguo DONG
;
Hesheng LUO
;
- Publication Type:Journal Article
- Keywords:
colonic smooth muscles;
patch clamp;
Ca 2+ activated K + channels;
progesterones;
irritable bowel syndrome(IBS)
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effects of progesterone on contractile activity of smooth muscle stripes and the large conduction Ca 2+ activated K + currents (BK Ca ) of single colonic myocytes in female guinea pig proximal colons METHODS Stripes and single cells were separated acutely from guinea pig proximal colon Contractions of stripes were measured by isonic transducer, and Ca 2+ activated K + currents were recorded with an Axopatch 1D amplifier under conventional whole cell patterns RESULTS 64 8 ?mol?L -1 progesterone produced longitudinal stripes significantly re laxation(0 1792 g?0 0873 g, n =6, P
