Effect of taurine on endogenous nitric oxide in the development of lung injury after hind limbs ischemia-reperfusion in rats
- VernacularTitle:牛磺酸对大鼠肢体缺血再灌注所致肺损伤过程中内源性NO的影响
- Author:
Xiuli MEN
;
Lianyuan ZHANG
;
Yibing ZHANG
;
Shuyun DONG
;
Quanhui YANG
;
- Publication Type:Journal Article
- Keywords:
taurine;
reperfusion injury;
lung injury;
nitric oxide
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To evaluate the possible role of endogenous nitric oxide (NO) in the development of lung injury after hind limbs ischemia reperfusion (LIR), and the effect of taurine on endogenous NO on the model of lung injury following LIR. METHODS Wistar rats were divided into three groups: control group, ischemia reperfusion group (IR) and taurine+IR (Tau+IR). The changes of PaO 2 ,PaCO 2,lung index (LI) and lung permeability index (LPI) were observed. The content of malondialdehyde (MDA), NO and endothelin (ET) in both plasma and the lung as well as the content of nitric oxide synthase (NOS) and taurine in the lung were detected. The immunohistochemical method was used to detect level in the expression of NOS protein. RESULTS Taurine improved the pulmonary respiratory following LIR significantly, lightened lung edema, decreased the content of ET in both plasma and lung tissue, increased the content of NO in both plasma and lung tissue and promoted the level in the expression of NOS protein. CONCLUSION Using taurine may lighten lung injury following LIR and this protective effect may due to increasing the content of endogeneous NO and decreasing the level of ET.
