Role of [Ca~(2+)]i in the apoptosis of Jurkat T lymphoma cells induced by Tripterygium Hypoglaucum (Levl) Hutch alkaloids
- VernacularTitle:THH碱不通过钙离子信号通道诱导Jurkat淋巴瘤细胞株凋亡
- Author:
Lujun YANG
;
Wernera GRUNDLER
;
Michael NUESSE
;
Lin AO
;
Jia CAO
;
- Publication Type:Journal Article
- Keywords:
Tripterygium Hypoglaucum (Levl) Hutch alkaloids;
apoptosis;
calcium;
flow cytometry
- From:Journal of Third Military Medical University
2003;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the roles of [Ca 2+ ]i in the apoptosis of Jurkat cells induced by Tripterygium Hypoglaucum (Levl) Hutch alkaloids. Methods After Jurkat cells were stained with Indo 1 AM and PI, changes of [Ca 2+ ]i were assessed by flow cytometry at the single cell level. Results THH alkaloids could induce no changes of [Ca 2+ ] inside cytoplasm. Conclusion THH alkaloids induce the apoptosis of Jurkat cells via other pathways rather than via the [Ca 2+ ] pathway.
