Study on the acute toxicity of Tripterygium Hypoglaucum (Levl) Hutch solution in mice
- VernacularTitle:昆明山海棠水提液的急性毒性研究
- Author:
Lujun YANG
;
Houyong YU
;
Ping HUANG
;
Jian YUAN
;
Jia CAO
;
- Publication Type:Journal Article
- Keywords:
Tripterygium Hypoglaucum (Levl) Hutch;
acute toxicity;
LD 50
- From:Journal of Third Military Medical University
2003;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the acute toxicity and LD 50 of Tripterygium Hypoglaucum (Levl) Hutch(THH) solution to provide information for safe clinical application. Methods After oral administration of THH solution in mice, the mortality and the physiological and pathological changes were observed. Results The LD 50 (95% confidence limit) of THH in male and female mice was 79 g/kg(69～89 g/kg) and 100 g/kg (90～112 g/kg), respectively. No marked pathological change of the organs was found. Conclusion According to the standard of grading of acute toxicity, THH solution belongs to the moderate class. Therefore, it is safe in clinical practice and has a wide application.
