Characteristics of myocardial nuclear Ca~(2+)-ATPase after ischemia-reperfusion injury in rats
- VernacularTitle:心肌缺血再灌注损伤时细胞核被膜钙泵活性特征的研究
- Author:
Lezhi ZHANG
;
Ailing FA
;
Huamei HE
;
- Publication Type:Journal Article
- Keywords:
myocardial ischemia reperfusion injury;
nuclear Ca 2+ ATPase;
Ca 2+;
ATP;
ADP;
AMP
- From:Journal of Third Military Medical University
2003;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the regulatory effects of Ca 2+ , ATP, ADP and AMP on myocardial nuclear Ca 2+ ATPase activity after ischemia reperfusion injury Methods The model of myocardial ischemia reperfusion injury was established in rats Myocardial nuclei were purified using sucrose density gradient centrifugation The activity of Ca 2+ ATPase was measured with ascertaining phosphate Results Compared with the control, plasma levels of MDA and FFA after myocardial ischemia reperfusion injury increased significantly ( P
