Effects of antihypertensive agent on cardiac hypertrophy in hypertensive rats induced by high salt diet combined with cold stress
- VernacularTitle:降压药物干预高盐饮食复合冷应激诱导大鼠的心肌肥厚
- Author:
Ziqiang WU
;
Zhiming ZHU
;
Shanjun ZHU
;
Haiyan WANG
;
- Publication Type:Journal Article
- Keywords:
high salt diet;
cold stress;
hypertension;
cardiac hypertrophy;
antihypertensive
- From:Journal of Third Military Medical University
2003;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of antihypertensive agents on renin angiotensin aldosterone system, blood pressure and myocardial hypertrophy induced by high salt diet plus cold stress. Methods Fifty male Wistar rats weighting 200～250 g were divided into 5 groups: control, saline, captopril, betaloc and nitrendipine. The rats treated with dugs or saline were fed with high salt diet(8% NaCl) and subjected to cold stress 4 hours a day. Blood pressure and body weight were measured once a week. Rats were sacrificed and then the gross weight of hearts was measured 8 weeks later. Renin activity(RA), angiotensinⅡ(AngⅡ) and aldosterone(Aldo) in the left ventricular wall were determined by radioimmunoassay. Results ① Levels of RA, AngⅡ and Aldo of rat left ventricular wall in betaloc group were significantly lower than those in saline, captopril and nitrendipine groups( P
