A preliminary study of the relationship between the (C-106T) single nucleotide polymorphism in the aldose reductase gene promoter region and diabetic nephropathy
- VernacularTitle:醛糖还原酶基因启动区(C-106T)单核苷酸多态性与糖尿病肾病关系的初步研究
- Author:
Qian XIAO
;
Yuhong ZHANG
;
Shuping WANG
;
- Publication Type:Journal Article
- Keywords:
type 2 diabetes;
single nucleotide polymorphism;
diabetic nephropathy;
aldose reductase gene
- From:Journal of Third Military Medical University
2003;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the (C 106T) single nucleotide polymorphsim of promoter region of aldose reductase gene and type 2 diabetes mellitus with nephropathy in Chinese Han from Chongqing. Methods The (C 106T) allele and genotype of 192 patients of type 2 diabetes were examined by polymerase chain reaction agarose gel electrophoresis and restriction enzyme Bfa Ⅰ. Results The frequencies of both allele C and genotype CC were significantly higher in type 2 diabetes patients with albuminuria than in those without albuminuria. Logistic regression analysis showed that allele C and genotype CC were associated with diabetic nephropathy in type 2 diabetes mellitus patients( P =0.032 and 0.046, respectively). Conclusion This finding suggests that (C 106T) single nucleotide polymorphism in the aldose reductase gene promoter region may be associated with diabetic nephropathy of Chinese Han type 2 diabetes. It may be a functional polymorphism and can serve as an inherited marker for susceptibility of diabetic nephropathy.
