Advance in research on cholinergic theory of Alzheimers disease
- VernacularTitle:阿尔采末病胆碱能学说研究进展
- Author:
Chongbo ZHONG
;
Xianghua XU
;
Xiaoliang WANG
;
- Publication Type:Journal Article
- Keywords:
Alzheimers disease;
acetylcholine;
central cholinergic system;
dementia
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
It is generally agreed that the central cholinergic system plays an important role in learning and memory processes. Alzheimers disease (AD), the most common cause of dementia, is a devastating illness characterized by progressive cognitive deterioration. The learning and cognitive deficits observed in AD patients are hypothesized to be partly caused by central cholinergic system dysfunction. There exists a malicious cycle in the pathologic course of AD, that is, the impairment of central cholinergic transmission could increase the amount of A? in the brain, and the increase of A? could also impair the efficacy of the cholinergic transmission.
