New light on neuronal ATP-sensitive potassium channels
- VernacularTitle:神经元ATP敏感钾通道的研究进展
- Author:
Yingli ZHANG
;
Hai WANG
;
- Publication Type:Journal Article
- Keywords:
ATP sensitive potassium channels;
sulphonylurea receptor;
ischemia;
Parkinsons disease
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
ATP sensitive potassium (K ATP ) channels widely expressed in many tissue and cell types including neurons are heteromultimers of sulfonylurea receptor (SUR) and inward rectifier K + channel (Kir6) subunits associated with 1∶1 stoichiometry as a tetramer (SUR/Kir6) 4. The activity of K ATP channels is modulated by intracellular ATP concentrations. Neuronal K ATP channels are involved in the mediation of glucose sensing and metabolic stress. Under physiological condition, they also possess important pathophysiological functions in acute brain ischemic and chronic neurodegenerative diseases.
