Regulation of dopamine and glutamate release by metabotropic glutamate receptors in the basal ganglia motor circuit:implications for treatment of parkinsons disease
- VernacularTitle:亲代谢型谷氨酸受体对基底神经节多巴胺和谷氨酸释放的调节
- Author:
Changhong MENG
;
Gang HU
;
- Publication Type:Journal Article
- Keywords:
metabotropic glutamate receptor;
basal ganglia;
parkinsons disease;
dopamine;
glutamate
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Metabotropic glutamate receptors (mGluRs) are a family of G protein coupled receptors linked to modulation of ion channel functions and multiple second messengers. These receptors are widely distributed throughout the basal ganglia (BG). Studies have demonstrated that these mGluRs subtypes located at various synapses in BG could modulate the release of dopamine and glutamate which correlates with brain area,the subtype selectivity and concentration of the ligands. Metab otropic glutamate receptors have been proposed as potentially new therapeutic targets for Parkinsons disease by providing a method of pharmacologically regulating neurotransmission in the BG.
