Thrombolytic effect of non-hemorrhagic fibrinolytic enzyme purified from Agkistrodon acutus on animal thrombosis
- VernacularTitle:尖吻蝮蛇毒无出血活性纤溶酶对动物血栓的溶栓作用
- Author:
Zhaoyan LI
;
Bin YANG
;
Shuangyi TANG
;
Danqing LEI
;
- Publication Type:Journal Article
- Keywords:
agkistrodon acutus;
fibrinolytic enzyme;
thrombus
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the thrombolytic effect of non hemorrhagic fibrinolytic enzyme from Agkistrodon acutus venom on animal thrombosis. METHODS By means of pulmonary embolism,arterial thrombosis model in rabbits and venous thrombosis model in rats. The non hemorrhagic fibrinolytic enzyme from Agkistrodon acutus was given by intravenous injection at 0 14, 0 7, 1.4 mg?kg -1 three different doses respectively. Normal saline was used as negative control and thrombolytic effects was observed. RESULTS It was showed that moist weights of arterial thrombosis, venous thrombosis and pulmonary embolism were markedly lightened and has statistical significance compared with normal saline ( P
