Effects of rotenone on NOS activity and NO concentration in caudatum and plasma in rats
- VernacularTitle:鱼藤酮对大鼠尾核及血浆中NOS活性和NO含量的影响
- Author:
Yunpeng LI
;
Zhaojun DONG
;
Shu YANG
;
- Publication Type:Journal Article
- Keywords:
rotenone;
nitric oxide;
nitric oxide synthase;
caudatum;
plasma
- From:Journal of Third Military Medical University
2003;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the rotenone induced changes of nitric oxide (NO) concentration and nitric oxide synthase (NOS) activity in rat caudate nuclei and blood plasma. Methods Wistar rats were daily administrated with rotenone at the doses of 0.335, 0.670 and 1.005 mg/kg(sc). Animals were sacrificed on days 30, 60 and 90. The NO concentration and the NOS activity in the caudate nuclei and blood plasma were determined by biochemical methods. Results At each time point of days 30, 60 and 90, rotenone induced significant increases in NO concentration and NOS activity in both the caudate nuclei and blood plasma in dose and time dependent manners. Conclusion Long term exposure to rotenone leads to the increase of nitric oxide and nitric oxide synthase in brain tissues and blood plasma in rat.
