Effect of ischemic preconditioning on cardiac function in hyperlipidemic rats
- VernacularTitle:缺血预处理对高血脂大鼠心功能的影响
- Author:
Xiaoyi ZHANG
;
Wenhong HUANG
;
Xiuping SHI
;
Ruichang LU
;
- Publication Type:Journal Article
- Keywords:
hyperlipidemia;
ischemic preconditioning;
reperfusion;
cardiac function
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
This paper is to investigate the effect of ischemic preconditioning on cardiac function in the hyperlipidemic rats.The alterations of LVSP,(d p /d t ) max , GSH Px, SOD and MDA were measured in ischemia/reperfusion group, ischemic preconditoning group and control group with in vitro myocardial ischemic precondioning model. The level of LVSP, (d p /d t ) max , GSH Px and SOD was significantly higher in the preconditoning group than that in the ischemia/reperfusion group, and these values were close to those in the control group. The area of contraction component in P cycle was higher and the amount of MDA was lower, whereas the level of LVSP, (d p /d t ) max declined significantly in ischemia/reperfusion group.It is suggested that ischemic preconditoning in hyperlipidemic rats can reduce cardiac functional impairment due to ischemia/reperfusion injury, and may have myocardial protective effects.
