Oxaliplatin combining fluorouracil and folinic acid in treatment of locally advanced and metastatic gastric cancer
- VernacularTitle:奥沙利铂联合5-氟尿嘧啶和甲酰四氢叶酸治疗晚期和复发性胃癌的临床分析
- Author:
Yi WANG
;
Zhiqian HU
;
Hui ZHOU
;
Qiang WANG
;
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
oxaliplatin;
5 fluorouracil;
folinic acid;
drug therapy,combination
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the efficacy and safety of an oxaliplatin, fluorouracil (5 FU), and folinic acid (FA) combination in treatment of patients with metastatic or advanced gastric cancer,we used oxaliplatin 130 mg/m 2 (2 hour intravenous infusion,1 d)and FA 200 mg/m 2 (2 hour intravenous infusion,1 to 5 d) followed by 5 FU 500 mg/m 2 (4 hour continuous infusion,1 to 5 d) every 3 weeks. Efficacy of treatment was evaluated after 3 cycles and the responders were confirmed 4 weeks later. In 26 case evaluated, patial release was achieved in 11 cases, stablized in 9 cases, progressed in 6 cases. The overall response rate was 42.3%. The main adverse effects were gastrointestinal tract toxicity, neurosensory toxicity and bone marrow suppression. This trail suggested that the short term curative effect of this regimen was similar to those of others and showed good efficacy and an acceptable safety profile. It is a new option for the treatment of metastatic and advanced gastric cancer.
