Inhibitory effect of urinary trypsin inhibitor on IL-6 expression in severe acute pancreatitis in rats
- VernacularTitle:大鼠重症急性胰腺炎过程中UTI抑制IL-6表达的研究
- Author:
Jianying BAI
;
Hong GUO
;
Xiaoyan ZHAO
;
- Publication Type:Journal Article
- Keywords:
urinary trypsin inhibitor;
severe acute pancreatitis;
interleukin 6;
rats
- From:Journal of Third Military Medical University
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of human urinary trypsin inhibitor(UTI) in severe acute pancreatitis (SAP). Methods UTI was highly purified from the urine of patients with acute pancreatitis by column chromatography. SAP models were established by injection of 5% sodium taurocholate(NaTc) at dose of 0.1 ml/100 g weight under pancreatic capsule. The interleukin 6(IL 6) level in each group was measured by ELISA. Results ① The highly purified UTI with high yield was harvested. ② SAP models were established successfully. ③ The level of IL 6 in SAP group was significantly higher than that in NC, but in UTI group, the increase was not obvious. Conclusion The alleviating effect of UTI on the pathological damage degree in rats with SAP is related to the inhibitive effect of UTI on the expression of IL 6.
