Effect of glutamine on intestinal mucosal barrier function and antioxidative capacity in rats with radiation injury
- VernacularTitle:谷氨酰胺对放射损伤大鼠肠粘膜屏障功能和抗氧化能力的影响
- Author:
Shanjun ZHENG
;
Baoquan JIANG
;
Rong TANG
;
Dandan MAO
;
- Publication Type:Journal Article
- Keywords:
glutamine;
radiation injury;
intestinal mucosal barrier;
antioxidation
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of glutamine on gut barrier function and antioxidative capacity in rats with radiation damage. Methods A total of 30 healthy Wistar male rats were randomly divided into three groups: control group, GLN enriched group(+GLN) and GLN free group( GLN). Rats in control and GLN group were fed with a basic diet, while 3% GLN was added into the diet of the +GLN group. On the 15th day, rats in GLN and +GLN groups received 9.0 Gy 60 Co ? irradiation in total body. The rate of the gut bacterial translocation and the level of endotoxin, GSH and SOD in the serum were determined at the end of the experiment. Results The rate of bacterial translocation and serum endoxin level were significantly lower in +GLN than in GLN, and GSH and SOD levels in serum were significantly higher in +GLN than in GLN. Conclusion Glutamine supplement is helpful to protect the gut barrier function and improve the antioxidation capacity in rats with radiation injury.
