Study of the effects of aging on NO-cGMP pathway and sexual hormone in rat penile tissue
- VernacularTitle:增龄对大鼠阴茎组织中NO-cGMP通路及性激素的影响研究
- Author:
Xiaojun WU
;
Jiahua ZHANG
;
Bo SONG
;
Xiyu JIN
;
- Publication Type:Journal Article
- Keywords:
penile erection;
aging;
nitric oxide(NO);
cGMP;
sexual hormone
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of aging on NO cGMP pathway and sexual hormone in penile tissue of different age rats. Methods The nitric oxide(NO) and cyclic guanosine monophosphate(cGMP) contents, nitric oxide synthase(NOS) activity in penile tissue and testosterone(T) and luteinizing hormone(LH) contents in blood of rats of different ages(2, 8, 16 and 24 months) were detected. Results With age increasing, ① The NO content of penile tissue firstly rose(8 months, the highest ) then dropped (24 months, the lowest), being the same as the variation of NOS( P
