The changes of electrophysiology of the rat with cathartic colon and reaction to acetylcholine
- VernacularTitle:“泻剂结肠”大鼠结肠肌电活动及其对乙酰胆碱反应的变化
- Author:
Xiankai HUANG
;
Jitai XU
;
Weidong TONG
;
- Publication Type:Journal Article
- Keywords:
slow transit constipation;
cathartic colon;
gastrointestinal electrophysiology
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the etiopathology of slow transit constipation(STC). Methods The model of rat with cathartic colon was established and the changes of colonic electromyography and reaction to acetylcholine(Ach) were examined. Result The frequency, amplitude of slow wave and colon reaction to Ach of rats with cathartic colon decreased markedly. Conclusion Long term abuse of stimulant laxatives could damage enteric nervous system(ENS) and accelerate the pathological changes of STC.
