Subconvulsive electrical stimuli facilitate increased NO level and neuronal NOS expression in hippocampi of rats
- VernacularTitle:惊厥阈下电刺激致大鼠海马NO含量及nNOS表达变化
- Author:
Qingsong WANG
;
Zhengguo WANG
;
Peifang ZHU
;
- Publication Type:Journal Article
- Keywords:
electrical stimulation;
hippocampus;
nitric oxide;
neuronal NO synthase;
traumatic stress disorder;
posttraumatic
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the alterations of nitric oxide (NO) level and the neuronal NOS (nNOS) expression in rats with posttraumatic stress disorder (PTSD) like behavior following subconvulsive electrical stimuli. Methods After the establishment of the PTSD animal model following subconvulsive stimuli to hippocampus, the nitric oxide (NO) and NO synthase (NOS) levels and the neuronal NOS (nNOS) expression in hippocampus and frontal cortex of experimental rats were investigated by neurochemistry and Western blotting, respectively. Results The NO level in hippocampus of experimental rats with PTSD like behavior following subconvulsive stimulation increased significantly at 12 h after the last stimulation (4.65?1.22 ?mol/g protein, P
