Expressions of CD44, CD44V3, CD44V6 and PCNA in human osteosarcoma and the clinical significance
- VernacularTitle:粘附分子CD44、CD44V3、CD44V6及PCNA在人骨肉瘤中的表达及其临床意义
- Author:
Rong XIN
;
Qiaonan GUO
;
Junming FENG
;
- Publication Type:Journal Article
- Keywords:
osteosarcoma;
immunohistochemistry;
CD44;
antigen;
PCNA
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expressions of CD44, CD44V3, CD44V6 and PCNA and the relationship between the expressions and clinical pathologic changes of human osteosarcoma Methods The expressions of CD44, CD44V3, CD44V6 and PCNA in 15 osteochondromas and 40 osteosarcomas were detected immunohistochemically Results (1) The positive expression rates of CD44, CD44V3 and CD44V6 in osteosarcoma were markedly higher than those in osteochondroma (2) The positive expression rate of CD44V6 was higher than those of CD44 and CD44V3 in osteochondroma (3) The expression of CD44V6 was not involved in the pathological type or the prognosis in osteochondroma (4) The expressions of CD44 and CD44V6, particularly that of CD44V6, were closely involved in the PCNA positive rate Conclusion CD44V6 might act as a marker of malignancy of the bone tumors, but the relationship with the prognosis in malignant bone tumors waits to be further studied
