The changes and significance of the expression of HSP90? in the liver of severely scalded rats
- VernacularTitle:严重烫伤大鼠肝脏热休克蛋白90?的表达变化及意义
- Author:
Junping WANG
;
Yongping SU
;
Xianhua LIU
;
Jinghong ZHAO
;
Rong QIN
;
- Publication Type:Journal Article
- Keywords:
severe scald;
liver;
rats;
HSP90?
- From:Journal of Third Military Medical University
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of the expression of HSP90? in the liver of severely scalded rats at the early stage of stress Methods The expression levels of HSP90? in the liver of rats at different time points after severe scald were detected by Western blotting and then the expression of HSP90? in the nucleuses was observed by immunohistochemistry Results The expression of HSP90? significantly increased in the liver of rats after severe scald, especially during 12～48 h Abnormal high expression of HSP90? in the nucleuses around was found at 48 h after scald Conclusion The abnormal high expression of HSP90? due to severe scald may be one of the important causes resulting in the disorder of glucocorticoid receptor at the early stage of stress after severe trauma.
