Effects of carvedilol on cardiomyocyte apoptosis and sarcoplasmic reticulum Ca~(2+) AT-Pase activity in rats with congestive heart failure
- VernacularTitle:卡维地洛干预心衰对大鼠心肌细胞凋亡和肌浆网钙泵活性的影响
- Author:
Zhaohua GENG
;
Longgui LI
;
Qiang WU
;
- Publication Type:Journal Article
- Keywords:
congestive heart failure;
sarcoplasmic reticulum Ca 2+ pump;
apoptosis;
? blocker
- From:Journal of Third Military Medical University
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of carvedilol therapy of congestive heart failure. Methods After chronic heart failure model was established by ligation of the left coronary artery in rats, rats were treated with carvedilol and terazosin. Then hemodynamic parameters, activity of sarcoplasmic reticulum(SR) Ca 2+ pump(SERCA 2a ) and the rate of cardiomyocyte apoptosis were determined. Results Compared with those of the control group( group C), the activity of SR Ca 2+ pump in the heart failure group(group F) decreased( P 0.05). Carvedilol intervention reduced the rate of cardiomyocyte apoptosis, but enhanced the activity of SR Ca 2+ pump significantly in dose dependent manner. The activity of SR Ca 2+ pump was negatively correlated with the rate of cardiomyocyte apoptosis( r =-0.814, P
