The study of E-cadherin gene abnormality in non-small cell lung cancer
- VernacularTitle:非小细胞肺癌E-钙粘蛋白基因异常的研究
- Author:
Guoqiao ZHANG
;
Zhixin WANG
;
Xin LIU
;
- Publication Type:Journal Article
- Keywords:
non small cell lung cancer;
E cadherin gene;
PCR SSCP
- From:Journal of Third Military Medical University
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the E cadherin gene abnormality in non small cell lung cancer(NSCLC). Methods E cadherin gene mutations in exons 6, 7, 8 and 9 in 24 cases of non small cell lung cancer were studied by PCR SSCP and DNA sequence analysis. Results Abnormality of the E cadherin gene was found in exon 9 by means of insertion, deletion and mutation in 2 cases. Conclusion Abnormality of E cadherin gene is present in NSCLC by means of insertion and deletion in extracelluar matrix. The main cause of the decrease in epithelial adhesion may be resulted from the abnormality gene change of the E cadherin.
