Effect of Rhizoma Atractylodis Macrocephalae on electrogastric arrhythmia in rats and its mechanisms
- VernacularTitle:中药白术对大鼠胃肌电紊乱调节作用的机制探讨
- Author:
Jinzhao ZHU
;
Jie ZHANG
;
Enren LENG
;
- Publication Type:Journal Article
- Keywords:
Rhizoma Atractylodis Macrocephalae;
electrogastrogram;
substance P;
vasoactive intestinal peptide;
nitric oxide synthase
- From:Journal of Third Military Medical University
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Rhizome Atractylodis Macrocephalae (RAM) on electrogastric arrhythmia in rats and its mechanisms. Methods A total of 30 Wistar rats were randomly divided into 3 groups: control group, model group and RAM plus model group. The frequency of slow wave(FSW), coefficient of variation(CV) and abnormal rhythm index(ARI) were recorded and analyzed by computer. The substance P(SP), vasoactive intestinal peptide(VIP) and nitric oxide synthase(NOS) nerves in antral myenteric plexus were observed by immunohistochemical staining. Results Compared with those of the control group, the CV and ARI in model group markedly increased( P 0.05). The denites of SP nerves markedly decreased( P 0.05). Conclusion RAM has regulative effect on the electrogastric arrhythmia in rats and the mechanisms may be related with the increased SP nerves and decreased VIP and NOS nerves in antral myenteric plexus.
