Expression of survivin and its correlation with cell proliferation and axillary lymph node metastasis in breast cancer
- VernacularTitle:乳腺癌中survivin蛋白的表达和PCNA及腋窝淋巴结转移的关系
- Author:
Rong XIN
;
Deyu GUO
;
Dongmei YU
;
Limei LIU
;
- Publication Type:Journal Article
- Keywords:
survivin;
breast cancer;
metastasis;
PCNA
- From:Journal of Third Military Medical University
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of survivin and its correlation with tumor cell proliferation and axillary lymph node metastasis in breast cancer. Methods Expressions of survivin and proliferating cell nuclear antigen(PCNA) in 74 cases of breast cancer(34 cases with axillary lymph node metastasis) were measured by immunohistochemistry. Results (1) There was expression of survivin in 64.9% of breast cancer. (2) Labeling idex(LI) of PCNA in breast cancer cells with positive expression of survivin was significantly higher than that with negative survivin. (3) The positive percent of survivin expression in breast cancer with axillary lymph node metastasis was higher than that without axillary lymph node metastasis. Conclusion The expression of survivin in breast cancer is related to PCNA and axillary lymph node metastasis.
