Enantioselective pharmacodynamics and pharmacokinetics of the 2-arylpropionic acid derivatives
- VernacularTitle:2-芳基丙酸类药物的立体选择性药效学及药动学
- Author:
Jingmin SHI
;
Qiaolin DENG
;
Duan LI
;
- Publication Type:Journal Article
- Keywords:
arylpropionic acid derivatives;
enantioselective;
pharmacodynamics;
pharmacokinetics
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The 2 arylpropionic acid derivatives, or "profens", are an important group of nonsteroidal antiinflammatory drugs (NSAIDs). Widely used members of this group include ibuprofen, naproxen, flurbiprofen, and etodolac. Most of these drugs were marketed as racemates, however the individual enantiomers differ in their pharmacological activity, mechanism and toxicity. This drug class is widely focused because of its various biologic properties that affect their clinical use. This review will demonstrate enantioselective pharmacodynamics and pharmacokinetics of "profens".
