Effects of cyproheptadine on pituitary-adrenalcortex axis in rats and its mechanism
- VernacularTitle:赛庚啶对大鼠垂体-肾上腺皮质轴作用及机制的研究
- Author:
Bai KANG
;
Gong DAI
;
Zhengbin LI
;
Guangzhou LI
;
Fengjie LI
;
Er GAO
;
- Publication Type:Journal Article
- Keywords:
cyproheptadine;
pituitary gland;
adrenalcortex;
ultramicrostructure;
calmodulin
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effects of cyproheptadine (Cyp) on endocrine functions and pituitary adrenalcortex axid in rats and its mechanism METHODS Radioimmunoassay(RIA)was used to measure the serum levels of ACTH and cortisone Ultramicrostructure of the ACTH cells and adrenalcortex and the calmodulin(CaM) mRNA expression of the pituitary and adrenalcortex were observed by electron microscope and the quantity PCR technique RESULTS Cyp 2 3 and 4 6 mg?kg -1 ?d -1 , ig for 14 d had significantly reduced the serum levels of ACTH and cortisone ( P
