Quantitative study of kinetic turbidimetric limulus test for bacterial endotoxins in cisplatin injection
- VernacularTitle:顺铂注射液细菌内毒素的动态浊度法定量研究
- Author:
Guinan XIAO
;
Zhaodi WU
;
Yongyuan GUAN
;
- Publication Type:Journal Article
- Keywords:
cisplatin injection;
bacterial endotoxins;
kinetic turbidimetric limulus tests;
interfering test
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the feasibility of bacterial endotoxins test for cisplatin injection. METHODS Gel clot and kinetic turbidimetric limulus tests were applied. RESULTS After diluted to 0 14 g?L -1 ,six batches of cisplatin injection didn't interfere with the test for bacterial endotoxins, others except three also didn't interfere with the test at the concentration of 0 28 g?L -1 ; The content of bacterial endotoxins in all samples tested was not more than 1 8 ZU?g -1 . CONCLUSION The kinetic turbidimetric limulus test provides a new way to detect the content of endotoxins in cisplatin injection, samples can be diluted to 0 14 g?L -1 to refute their interfering effects on routine bacterial endotoxins test.
