Inhibitory effect of pycnogenol on generation of advanced glycation end products in vitro
- VernacularTitle:碧罗芷体外抑制蛋白糖化终末产物生成作用的研究
- Author:
Tiemei ZHANG
;
Caihe HAN
;
Yiwen HAN
;
Huan GONG
;
Enyi ZHANG
;
Yan ZHANG
;
- Publication Type:Journal Article
- Keywords:
pycnogenol;
advanced glycation end products(AGEs);
antioxidant;
aminoguanidine
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the inhibitory effect of pycnogenol on generation of advanced glycation end products (AGEs) in vitro. METHODS Advanced glycation end products were determined by fluorospectrophotometer in the medium of 1 mol?L -1 glucose and 5% bovine albumin incubated at 37℃, 50℃, and 70℃ for different times. The inhibitory effect of pycnogenol was confirmed by the same system incubated with or without pycnogenol at different concentrations. RESULTS The rate of generation of AGEs in vitro was related with incubation time and incubation temperature. The generation of AGEs was inhibited by pycnogenol in vitro. The inhibitory rate was 10%～80% dependent on concentration and incubation time of pycnogenol. The inhibitory effect of pycnogenol on generation of AGEs was almost the same as that of Aminoguanidine at the same concentration. CONCLUSION pycnogenol could significantly inhibit generation of AGEs in vitro.
