Relation between activation of hippocampal astrocytes and ischemic tolerance induced by 3-nitropropionic acid in gerbils
- VernacularTitle:3-硝基丙酸预处理诱导沙土鼠脑缺血耐受与海马星形胶质细胞的激活
- Author:
Hongcan ZHU
;
Shenggang SUN
;
Hongge LI
;
- Publication Type:Journal Article
- Keywords:
pharmacodynamics;
3 nitropropionic acid;
cerebral ischemic tolerance;
astrocyte;
hippocampus;
gerbil
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the relationship between astroglial activation state and ischemic tolerance induced by low dose of 3 nitropropionic acid (3 NPA) in gerbil hippocampus. METHODS: Transient forebrain ischemic model was induced by bilateral common carotid arteries occlution. HE staining and immunohistochemistry were used to identify neuronal and astrocyte response. RESULTS: Preconditioning with 3 NPA produced protective effects of CA 1neurons. The number of glial fibrillary acidic protein positive astrocyte in hippocampal CA 1 region increased slightly in control group, but increased significantly in preconditioning of the brain with 3 nitropropionic acid. CONCLUSION: The state of astroglial activation is related to neuronal survival in ischemic tolerance induced by low dose of 3 nitropropionic acid.
